Bringing Liquid Biopsies to Clinical Practice

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Advancing Liquid Biopsy Assays into Clinical Routine

DeNovo provides all essential functions required to transform resource-heavy manual Circulating Tumor Cell (CTC) detection and analysis into an automated, high-throughput, high-capacity process that is suited to clinical practice. 

An all-in-one scanner designed to facilitate and automate the imaging, detection and characterization of CTCs, DeNovo introduces high levels of speed, standardization and sensitivity. Easy to operate, it can be integrated with any CTC enrichment method, as well as any combination of immunofluorescence and FISH markers.

Varied Samples. Optimal Process. Simple operation.

Any Enrichment Technique:

DeNovo was designed to preform automated imaging and analysis of various CTC enrichment techniques, supporting any geometric pattern and 3D structure.

Magnetic separation
Antibody Immobilization
Size filtration
Microfluidic chip

All Fluorescent Marker Combinations:

DeNovo supports any combination of DNA/RNA/Protein fluorescent markers.

Various Optical Configurations:

DeNovo’s optical configuration supports up to 6 different objectives, ranging from X1.25 to X100, including oil immersion objectives as well as mount of up to 6 different fluorescent filters ranging from UV to far red spectrum.

Large Capacity:

DeNovo supports up to 40 samples per unattended scan batch. An integrated barcode reader identifies the sample ID and all relevant information including enrichment technique and marker combination. Sample specific scan program is automatically selected based on identified information.

High Throughput 3D Imaging:

DeNovo utilizes advanced focus and imaging techniques specifically designed to meet the challenges associated with the 3D geometric structure of various enrichment devices, as well as those associated with the need to cover large scan area at minimum time.

Advanced Algorithmic Tools:

At the heart of automated CTC detection, DeNovo's innovative combination of deep learning algorithms with features based analysis. DeNovo automatically measures dozens of sophisticated biometric attributes, used to form assay specific CTC gating criteria, and assist in assay development. Combined with the trainable, innovative deep learning algorithms, it further improves detection sensitivity and specificity. Analysis is performed in parallel to the automated imaging, allowing review of results as soon as scan is completed.

Simple Usability:

DeNovo is operated through an integrated touch screen, enabling load and launch operation in a single click.

Offline Review and Analysis:

DeNovo was designed to ease and streamline processes, by enabling review and analysis of test results in parallel to the automated scan operation, performed at the comfort of the expert’s own desk using dedicated review and analysis workstation or using web browser from any computer. 

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